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Typo3 acceleration experience

How to accelerate Typo3 for a page with relative high load?

No statistically significant data but just a few benchmarks (made with ab) for the feeling:

Typo3 (no_cache = 1): ~ 1 rq/s
Typo3 (with cache): ~ 3 rq/s
Typo3 (with cache and eAccelerator): ~ 50 rq/s
Typo3 (with cache, eAccelerator and Squid reverse proxy): ~ 2000 rq/s

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